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KMID : 0370220100540020102
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Yakhak Hoeji
2010 Volume.54 No. 2 p.102 ~ p.105
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Activation of Hypoxia Inducible Factor-1 Alpha by Estrogen Receptor Alpha
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Rye Kwang-Hee
Lee Young-Joo
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Abstract
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Our previous results showed that hypoxia inducible factor-1 (HIF-1) activated estrogen receptor (ER) in the absence of ligand. In this study, we have studied the effect ER overexpression on the activation of HIF-1. ER overexpression induced transcription activation of hypoxia response element driven luciferase and vascular endothelial growth factor. As a negative control, the effect of ER on androgen receptor response element was used. Our result indicate that the two ER and HIF-1 signaling pathways shares part of the activation pathway.
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KEYWORD
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hypoxia, ER, HIF-1, VEGF
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